Thematic Review Series: Proteomics. Proteomic analysis of lipid-protein complexes

Proteomic analysis of lipid-protein complexes

Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the prenylated protein to membranes. The REP-like protein Rab GDP dissociation inhibit...

Overview and introduction: thematic review series on intestinal lipid metabolism.

Journal of Lipid Research Volume 56, 2015 487 Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc. The last decade has seen extraordinary advances in our understanding of intestinal lipid metabolism, driven at least in part through attempts to mitigate the ongoing epidemic of obesity and metabolic disease ( 1 ). For example, weight loss strategies including gast...

Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I.

More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational modification by the covalent attachment of an isoprenoid lipid (prenylation). Prenylated proteins include members of the Ras, Rab, and Rho families, lamins, CENPE and CENPF, and the gamma subunit of many small heterotrimeric G proteins. This modification is catalyzed by the pro...

Thematic review series: The Pathogenesis of Atherosclerosis

This is the first of a series of reviews of the controversy that swirled around the “lipid hypothesis” of atherosclerosis for so many years. Today, in the era of the statins, there is no longer any doubt about the value of decreasing blood cholesterol levels. In fact, “the lower the better” is the position of many clinicians. However, getting to this point has been a long uphill battle marked b...